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#crispr

4 posts4 participants0 posts today
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He conversado con @mruizbanos en su programa #Ágora de @aragonradio sobre esta eliminación del cromosoma 21 extra característico del síndrome de #Down mediante una estrategia experimental usando las herramientas #CRISPR de momento solo en células humanas.
cartv.es/aragonradio/podcast/e

CARTVAvance sorprendente para la eliminación de la copia adicional del ‘cromosoma 21’ (síndrome de Down), e investigación en enfermedades raras
Continued thread

Hoy reflexiono desde la ética en el observatorio de bioética de la Fundación Pablo VI del avance conceptual que nos llega desde Japón: usar #CRISPR para eliminar la trisomía del cromosoma 21 causante del síndrome de #Down ¿Debemos explorar esta posible terapia? Yo digo que sí.
fpablovi.org/analisis-actualid

www.fpablovi.org¿Curar el Síndrome de Down?Todos aquellos que nos dedicamos a investigar en alguna de las ciencias de la vida tenemos por objetivo, explícito o implícito, la salud de todas las perso...

La versatilidad de las herramientas de edición genética #CRISPR ha hecho posible que unos investigadores japoneses diseñen una estrategia para eliminar el tercer cromosoma 21 de la trisomía causante del síndrome de #Down. Te lo explico en @theconversationes
theconversation.com/descubiert

The ConversationDescubierto un posible tratamiento para curar el síndrome de Down mediante edición genética
More from The Conversation ES

La banana perfetta esiste, ed è figlia della genetica. A marzo arrivano (non in Italia) le prime banane modificate con CRISPR che non diventano marroni quando le tagliate. Stesso gusto, stessa consistenza, ma vita più lunga e zero sprechi. E presto ci saranno anche versioni resistenti al temibile fungo che minaccia le piantagioni globali. La rivoluzione gialla è servita, ma piacerà a tutti?

#Biotecnologia #Banane #CRISPR #Innovazione #Food #Futuro #Agricoltura

futuroprossimo.it/2025/02/a-ma

Kingdom-Wide CRISPR Guide Design with ALLEGRO

biorxiv.org/content/10.1101/20

bioRxiv · Kingdom-Wide CRISPR Guide Design with ALLEGRODesigning CRISPR single guide RNA (sgRNA) libraries targeting entire kingdoms of life will significantly advance genetic research in diverse and underexplored taxa. Current sgRNA design tools are often species-specific and fail to scale to large, phylogenetically diverse datasets, limiting their applicability to comparative genomics, evolutionary studies, and biotechnology. Here, we present ALLEGRO, a combinatorial optimization algorithm able to design minimal, yet highly effective sgRNA libraries targeting thousands of species. Leveraging integer linear programming, ALLEGRO identified compact sgRNA sets simultaneously targeting several genes of interest for over 2,000 species across the fungal kingdom. We experimentally validated the sgRNAs designed by ALLEGRO in Kluyveromyces marxianus , Komagataella phaffii , and Yarrowia lipolytica . In addition, we adopted a generalized Cas9-Ribonucleoprotein delivery system coupled with protoplast transformation to extend ALLEGRO's sgRNA libraries to other untested fungal genomes, such as Rhodotorula araucariae . Our experimental results, along with cross-validation, show that ALLEGRO enables efficient CRISPR genome editing, supporting the development of universal sgRNA libraries applicable to entire taxonomic groups. ### Competing Interest Statement The authors have declared no competing interest.