AnungIkwe ᐊᓈᓐg ᐃᑴTHE ROLE SSRIs PLAY IN VIOLENT CRIME<br><br>Vimeo Panorama - A Prescription for Murder<br><a href="https://vimeo.com/483163689" rel="nofollow noopener noreferrer" target="_blank">https://vimeo.com/483163689</a><br><br>James Eagan Holmes, the Aurora Colorao shooter, opened fire on a Century 16 movie theater on July 20, 2012. Search warrants revealed that James Holmes was taking a chemical cocktail of psychiatric drugs, including Sertraline, a generic version of Zoloft (antidepressant) and Clonazepam, a benzodiazepine drug known to have "hypnotic properties."<br>His shrink had recently increased his dosage of Sertraline 3 times.<br><br>Nearly every mass shooting that has taken place in America over the past two decades is now linked to psychiatric drugs. <br><br>Shelley Jofre investigates if a rare side effect of commonly prescribed anti-depressant SSRI has played a part in a number of killings including the mass murder at the premiere of a Batman film in Colorado in 2012<br><br>If it won't play, try watching it in Yandex preview <br><a href="https://yandex.com/video/preview/12514766904783882794" rel="nofollow noopener noreferrer" target="_blank">https://yandex.com/video/preview/12514766904783882794</a><br><br><br><a class="hashtag" href="https://spinster.xyz/tag/ssris" rel="nofollow noopener noreferrer" target="_blank">#SSRIs</a> <a class="hashtag" href="https://spinster.xyz/tag/serotonintheorydebunked" rel="nofollow noopener noreferrer" target="_blank">#SerotoninTheoryDebunked</a> <a class="hashtag" href="https://spinster.xyz/tag/therapy" rel="nofollow noopener noreferrer" target="_blank">#Therapy</a> <a class="hashtag" href="https://spinster.xyz/tag/psychiatry" rel="nofollow noopener noreferrer" target="_blank">#Psychiatry</a> <a class="hashtag" href="https://spinster.xyz/tag/pseudoscience" rel="nofollow noopener noreferrer" target="_blank">#Pseudoscience</a> <a class="hashtag" href="https://spinster.xyz/tag/skeptic" rel="nofollow noopener noreferrer" target="_blank">#Skeptic</a> <a class="hashtag" href="https://spinster.xyz/tag/medicalquackery" rel="nofollow noopener noreferrer" target="_blank">#MedicalQuackery</a> <a class="hashtag" href="https://spinster.xyz/tag/freespeech" rel="nofollow noopener noreferrer" target="_blank">#Freespeech</a> <a class="hashtag" href="https://spinster.xyz/tag/freethinkers" rel="nofollow noopener noreferrer" target="_blank">#Freethinkers</a> <a class="hashtag" href="https://spinster.xyz/tag/propaganda" rel="nofollow noopener noreferrer" target="_blank">#Propaganda</a> <a class="hashtag" href="https://spinster.xyz/tag/bigpharma" rel="nofollow noopener noreferrer" target="_blank">#BigPharma</a> <a class="hashtag" href="https://spinster.xyz/tag/gaslighting" rel="nofollow noopener noreferrer" target="_blank">#Gaslighting</a> <a class="hashtag" href="https://spinster.xyz/tag/junkscience" rel="nofollow noopener noreferrer" target="_blank">#JunkScience</a> <a class="hashtag" href="https://spinster.xyz/tag/ssridebunk" rel="nofollow noopener noreferrer" target="_blank">#SSRIDebunk</a> <a class="hashtag" href="https://spinster.xyz/tag/maleviolence" rel="nofollow noopener noreferrer" target="_blank">#MaleViolence</a> <a class="hashtag" href="https://spinster.xyz/tag/jamesholmes" rel="nofollow noopener noreferrer" target="_blank">#JamesHolmes</a> <a class="hashtag" href="https://spinster.xyz/tag/aurora" rel="nofollow noopener noreferrer" target="_blank">#Aurora</a> <a class="hashtag" href="https://spinster.xyz/tag/colorado" rel="nofollow noopener noreferrer" target="_blank">#Colorado</a> <a class="hashtag" href="https://spinster.xyz/tag/gunviolence" rel="nofollow noopener noreferrer" target="_blank">#GunViolence</a> <a class="hashtag" href="https://spinster.xyz/tag/sertraline" rel="nofollow noopener noreferrer" target="_blank">#Sertraline</a> <a class="hashtag" href="https://spinster.xyz/tag/ssri" rel="nofollow noopener noreferrer" target="_blank">#SSRI</a>
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#sertraline
1 post · 1 participant · 0 posts today
SleepyCatten<p>Hey folks :FediverseSymbol: </p><p>It's been a while since we did a public update post on our mental health, so this is kind of overdue :MentalHealthFlagHeart:</p><p>In short, we are presently still struggling with depression, anxiety, and <a href="https://www.additudemag.com/what-is-executive-function-disorder/" rel="nofollow noopener noreferrer" target="_blank">executive dysfunction</a> most of the time. We have, however, seen some gradual improvements soley due to being signed off work, which is a major stressor.</p><p>Because we're still struggling, we asked our GP to look into potentially changing our prescription antidepressant from <a href="https://en.wikipedia.org/wiki/Sertraline" rel="nofollow noopener noreferrer" target="_blank">sertraline</a> (max dose of 200 mg daily) to something else. He advised he'd look into it.</p><p>Meanwhile, we decided to take a look for ourselves, using the data on the <a href="https://en.wikipedia.org/wiki/Monoamine_reuptake_inhibitor#Binding_profiles" rel="nofollow noopener noreferrer" target="_blank">binding profiles</a> of various monoamine reuptake inhibitor and checking which ones are listed on <a href="https://www.nice.org.uk/" rel="nofollow noopener noreferrer" target="_blank">NICE</a>. For any that were, we further checked that were licensed for use as an antidepressant.</p><p>After all that work, we basically realised that sertraline was likely the single best out of all the ones the NHS can prescribe, followed only by <a href="https://en.wikipedia.org/wiki/Paroxetine" rel="nofollow noopener noreferrer" target="_blank">paroxetine</a> :FaceExhaling: The major difference between the two is that paroxetine binds more to noradrenaline transport receptors, whereas sertraline binds more to dopamine ones. Both otherwise are <a href="https://www.drugs.com/compare/sertraline-vs-paroxetine" rel="nofollow noopener noreferrer" target="_blank">fairly comparable</a>.</p><p>We had been very much hoping that the NHS might prescribe some kind of balanced <a href="https://en.wikipedia.org/wiki/Serotonin%E2%80%93norepinephrine%E2%80%93dopamine_reuptake_inhibitor" rel="nofollow noopener noreferrer" target="_blank">SNDRI</a> antidepressant to boost our serotonin, noradrenaline, and dopamine levels roughly equally. However, whenever we found one, we found that it wasn't available on the NHS <strong>AND</strong> it had a <strong>lot</strong> of bad side effects :PleadingFace: </p><p>E.g.,</p><ul><li><a href="https://en.wikipedia.org/wiki/Butriptyline" rel="nofollow noopener noreferrer" target="_blank">butriptyline</a></li><li><a href="https://en.wikipedia.org/wiki/Nefazodone" rel="nofollow noopener noreferrer" target="_blank">nefazodone</a></li><li><a href="https://en.wikipedia.org/wiki/Sibutramine" rel="nofollow noopener noreferrer" target="_blank">sibutramine</a></li></ul><p>As an additional note, we have been taking a low dose (150 mg daily) of bupropion alongside sertraline for a while to try to get more executive function. We don't even have a date for an ADHD assessment yet, so we aren't able to try the main ADHD meds, as these are all controlled substances. </p><p>We <strong>were</strong> able to acquire and try atomoxetine alongside sertraline (in place of bupropion), as it's not a controlled substance, but this did <strong>not</strong> go well at all 😞 </p><p>Our research indicated that it'd be better for us to try another single antidepressant medication than keep combining sertraline with bupropion, as that comes with <a href="https://www.drugs.com/interactions-check.php?drug_list=440-0,2057-0" rel="nofollow noopener noreferrer" target="_blank">a higher risk of serotonin syndrome and seizures</a>. Plus we'd need to come off bupropion anyway in order to try any other ADHD med.</p><p>As such, we're going to steadily reduce our bupropion dose and come off this by the end of the week. We'll then see how we fare.</p><p>In terms of setting reasonable expectations, based on our sensitivity to atomoxetine and other stimulants, <strong>and</strong> the fact that we're AuDHD, we do not expect either of the main two ADHD meds (<a href="https://en.wikipedia.org/wiki/Methylphenidate" rel="nofollow noopener noreferrer" target="_blank">methylphenidate</a> and <a href="https://en.wikipedia.org/wiki/Lisdexamfetamine" rel="nofollow noopener noreferrer" target="_blank">lisdexamphetamine</a>) to work well for us 😔</p><p>All we can do right now is try to focus on getting the depression and anxiety under control, so that we can try to develop strategies to cope with and work around our lack of executive function.</p><p><a href="https://cultofshiv.wtf/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MentalHealth</span></a> <a href="https://cultofshiv.wtf/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> <a href="https://cultofshiv.wtf/tags/anxiety" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>anxiety</span></a> <a href="https://cultofshiv.wtf/tags/ExecutiveDysfunction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ExecutiveDysfunction</span></a> <a href="https://cultofshiv.wtf/tags/ADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ADHD</span></a> <a href="https://cultofshiv.wtf/tags/AuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AuDHD</span></a> <a href="https://cultofshiv.wtf/tags/neurodivergent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurodivergent</span></a> <a href="https://cultofshiv.wtf/tags/neurospicy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurospicy</span></a> <a href="https://cultofshiv.wtf/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://cultofshiv.wtf/tags/bupropion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bupropion</span></a></p>
SleepyCatten<p>Hey folks 👋</p><p>For those who don't already know, we're currently signed off work due to depression, anxiety, and burnout.</p><p>Our employer is supportive, but there are multiple, fundamental, ongoing issues with the organisation that no amount of individual support can resolve. We cannot go into more detail.</p><p>During the last 2 and a bit weeks, we've done a mixture of resting and doing tasks we've been meaning to do for ages, but neither had the time nor spoons to do.</p><p>We're still on 200 mg <a href="https://en.wikipedia.org/wiki/Sertraline" rel="nofollow noopener noreferrer" target="_blank">sertraline</a> (an <a href="https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor" rel="nofollow noopener noreferrer" target="_blank">SSRI</a>) daily, but we've made the switch from taking 150 mg <a href="https://en.wikipedia.org/wiki/Bupropion" rel="nofollow noopener noreferrer" target="_blank">bupropion</a> (an <a href="https://en.wikipedia.org/wiki/Norepinephrine%E2%80%93dopamine_reuptake_inhibitor" rel="nofollow noopener noreferrer" target="_blank">NDRI</a>) daily alongside to 40 mg <a href="https://en.wikipedia.org/wiki/Atomoxetine" rel="nofollow noopener noreferrer" target="_blank">atomoxetine</a> (an <a href="https://en.wikipedia.org/wiki/Selective_norepinephrine_reuptake_inhibitor" rel="nofollow noopener noreferrer" target="_blank">sNRI</a>, not an <a href="https://en.wikipedia.org/wiki/Serotonin%E2%80%93norepinephrine_reuptake_inhibitor" rel="nofollow noopener noreferrer" target="_blank">SNRI</a>) daily alongside. We're slowly titrating up to the recommend 80 mg dose. </p><p>As we came off the bupropion steadily, we definitely felt it (i.e., mood; executive function; energy etc.), but the effects are levelling off as our atomoxetine dose steadily increases.</p><p>The bupropion had helped us for a while, both with our mental health and some ADHD struggles, but could only do so much. As such, we decided to make the unorthodox switch to atomoxetine.</p><p>Bupropion is an atypical NDRI and antidepressant: it boosts noradrenaline and dopamine (to a lesser extent). However, it's only prescribed off licence for ADHD, as it's not been shown to be effective. Atomoxetine, conversely, is mainly used to treat ADHD in people who do not respond well to stimulants, such as <a href="https://en.wikipedia.org/wiki/Methylphenidate" rel="nofollow noopener noreferrer" target="_blank">methylphenidate</a>. It directly boosts noradrenaline and indirectly boosts dopamine in the prefrontal cortex by a decent amount.</p><p>Since we do not tolerate any stimulants well (even caffeine), atomoxetine is our best bet in terms of an ADHD med that also helps with our mental health.</p><p>Unlike bupropion, it doesn't have any major interactions with sertraline (only moderate), and we can take 40 mg <a href="https://en.wikipedia.org/wiki/Propranolol" rel="nofollow noopener noreferrer" target="_blank">propranolol</a> tablets alongside to help keep our anxiety under control, rather than turning straight to 10 mg <a href="https://en.wikipedia.org/wiki/Diazepam" rel="nofollow noopener noreferrer" target="_blank">diazepam</a> tablets. </p><p>So far, we're doing well with the switch, both physically and mentally, but it'll be a while before we know for sure whether this the ideal medication combination.</p><p>We are still very much in low power recovery mode, so don't expect anything much or consistent from us.</p><p>A last note to sign this off: from the above listed drugs, the only one we can currently get via the NHS is sertraline. We may be able to get atomoxetine through the NHS in the future, but that's dependent on us ever actually getting a formal ADHD diagnosis 😮💨 The waiting lists are rather long... even when using the <a href="https://www.nhs.uk/mental-health/social-care-and-your-rights/how-to-access-mental-health-services/#choice" rel="nofollow noopener noreferrer" target="_blank">Right To Choose</a> a mental health service provider.</p><p>Apologies for any typos.</p><p><a href="https://cultofshiv.wtf/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MentalHealth</span></a> <a href="https://cultofshiv.wtf/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> <a href="https://cultofshiv.wtf/tags/anxiety" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>anxiety</span></a> <a href="https://cultofshiv.wtf/tags/burnout" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>burnout</span></a> <a href="https://cultofshiv.wtf/tags/neurodivergent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurodivergent</span></a> <a href="https://cultofshiv.wtf/tags/ADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ADHD</span></a> <a href="https://cultofshiv.wtf/tags/AuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AuDHD</span></a> <a href="https://cultofshiv.wtf/tags/NHS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NHS</span></a> <a href="https://cultofshiv.wtf/tags/NHSEngland" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NHSEngland</span></a> <a href="https://cultofshiv.wtf/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://cultofshiv.wtf/tags/SSRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SSRI</span></a> <a href="https://cultofshiv.wtf/tags/bupropion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bupropion</span></a> <a href="https://cultofshiv.wtf/tags/NDRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NDRI</span></a> <a href="https://cultofshiv.wtf/tags/atomoxetine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>atomoxetine</span></a> <a href="https://cultofshiv.wtf/tags/sNRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sNRI</span></a> <a href="https://cultofshiv.wtf/tags/serotonin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>serotonin</span></a> <a href="https://cultofshiv.wtf/tags/noradrenaline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>noradrenaline</span></a> <a href="https://cultofshiv.wtf/tags/dopamine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dopamine</span></a> <a href="https://cultofshiv.wtf/tags/RightToChoose" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RightToChoose</span></a> <a href="https://cultofshiv.wtf/tags/propranolol" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>propranolol</span></a> <a href="https://cultofshiv.wtf/tags/diazepam" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>diazepam</span></a> <a href="https://cultofshiv.wtf/tags/stimulants" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>stimulants</span></a> <a href="https://cultofshiv.wtf/tags/methylphenidate" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>methylphenidate</span></a></p>
K'an<p>Started 50mg <a href="https://mastodon.social/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> on Monday. 2/3 of the day now feels like holding back tears and trying to mask a tsunami of fear, anxiety, self-doubt, impending doom, and the 3rd part is weirdly, PARANOIA. I suspect friends and loved ones of secretly hating and judging me, of installing spyware on my computer and cameras in my room and so on. This can't be a normal adjustment period, can it? I don't think I can handle 4-6 weeks of this shit just to see if something improves after I push through it all.</p>
SleepyCatten<p>Hey folks 👋</p><p>We'll <strong>try</strong> and keep this short, as we are running dangerous low on <a href="https://en.wikipedia.org/wiki/Spoon_theory" rel="nofollow noopener noreferrer" target="_blank">spoons</a>, which is kinda the purpose of this announcement :MentalHealthFlagHeart: </p><p>As you likely already know, we are a non-binary, trans fem, disabled, neurodivergent (<a href="https://embrace-autism.com/audhd/" rel="nofollow noopener noreferrer" target="_blank">AuDHD</a>) spoonie, who additionally struggles with major depression, requiring multiple meds daily in order to keep functioning at a full-time job :DisabilityPrideHeart: </p><p>Despite this, we have been pushing ourselves regularly beyond our limits, causing increasing tiredness and irritability, exacerbating many of our AuDHD traits, and leading to complete verbal shutdowns at times, as we so very much wanted to help as many people as we could :PleadingFaceWithRedHearts:</p><p>This has inevitably led to pretty-much complete burnout 🤦♀️</p><p>We'd already taken steps back in terms in terms of the amount and scale of support we were giving to people, as well as spending less time on fedi and other platforms, but it's not been enough 😞</p><p>As such, until further notice:</p><ul><li>We won't be streaming on <a href="https://www.twitch.tv/sleepycatten" rel="nofollow noopener noreferrer" target="_blank">our Twitch channel</a> and have deleted our <a href="https://www.twitch.tv/sleepycatten/schedule" rel="nofollow noopener noreferrer" target="_blank">schedule</a>.</li><li>We won't offer private support about gender affirming hormone therapy, mental health, or anything else.</li><li>We will largely be invisible on Discord and will not be on fedi as much as we used to be.</li></ul><p>Of course we feel guilty about this, but right now we <strong>need</strong> to put ourselves first, so that we can fully recover from this burnout, then take steps to reduce the risk of further recurrence.</p><p>We want to stress that we are stepping <strong>back</strong>, not stepping <strong>away</strong>, from everywhere and everyone.</p><p>We'll still be in contact with folks when we have spare spoons, and we'll still interact and post on fedi occasionally.</p><p>And we'll still be doing some helpful activities at work and behind the scenes that we can't discuss :TransHeart: ✊</p><p>But yeah: you won't see us as much, but it's because we're allowing ourselves to prioritise our own health and needs.</p><p><a href="https://cultofshiv.wtf/tags/streaming" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>streaming</span></a> <a href="https://cultofshiv.wtf/tags/streamer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>streamer</span></a> <a href="https://cultofshiv.wtf/tags/Twitch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Twitch</span></a> <a href="https://cultofshiv.wtf/tags/TwitchStreamer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TwitchStreamer</span></a> <a href="https://cultofshiv.wtf/tags/queer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>queer</span></a> <a href="https://cultofshiv.wtf/tags/trans" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>trans</span></a> <a href="https://cultofshiv.wtf/tags/transgender" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>transgender</span></a> <a href="https://cultofshiv.wtf/tags/enby" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>enby</span></a> <a href="https://cultofshiv.wtf/tags/femby" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>femby</span></a> <a href="https://cultofshiv.wtf/tags/NonBinary" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NonBinary</span></a> <a href="https://cultofshiv.wtf/tags/TransWoman" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TransWoman</span></a> <a href="https://cultofshiv.wtf/tags/TransFem" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TransFem</span></a> <a href="https://cultofshiv.wtf/tags/CatGirl" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CatGirl</span></a> <a href="https://cultofshiv.wtf/tags/LGBTQ" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LGBTQ</span></a>+ <a href="https://cultofshiv.wtf/tags/LGBTQIA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LGBTQIA</span></a>+ <a href="https://cultofshiv.wtf/tags/neurodivergent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurodivergent</span></a> <a href="https://cultofshiv.wtf/tags/neurospicy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurospicy</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyAutistic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyAutistic</span></a> <a href="https://cultofshiv.wtf/tags/ADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ADHD</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyADHD</span></a> <a href="https://cultofshiv.wtf/tags/AuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AuDHD</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyAuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyAuDHD</span></a> <a href="https://cultofshiv.wtf/tags/spoonie" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>spoonie</span></a> <a href="https://cultofshiv.wtf/tags/NoSpoonsOnlyKnives" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NoSpoonsOnlyKnives</span></a> <a href="https://cultofshiv.wtf/tags/disabled" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>disabled</span></a> <a href="https://cultofshiv.wtf/tags/disability" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>disability</span></a> <a href="https://cultofshiv.wtf/tags/burnout" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>burnout</span></a> <a href="https://cultofshiv.wtf/tags/VerbalShutdown" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>VerbalShutdown</span></a> <a href="https://cultofshiv.wtf/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MentalHealth</span></a> <a href="https://cultofshiv.wtf/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> <a href="https://cultofshiv.wtf/tags/SSRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SSRI</span></a> <a href="https://cultofshiv.wtf/tags/NDRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NDRI</span></a> <a href="https://cultofshiv.wtf/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://cultofshiv.wtf/tags/bupropion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bupropion</span></a></p>
SleepyCatten<p>Hey folks</p><p>Apologies that we've been AWOL and still haven't replied to a lot of your notifications 😞</p><p>The short version is that we've overextending ourselves (again) in terms of the support we've been giving people. This has led to us becoming overly tired, easily irritated, and emotionally spent. Our RSD (rejection sensitive dysphoria) is through the roof right now :PleadingFace: </p><p>The last time we pushed ourselves too far, we had an empathy overload (sometimes known as compassion fatigue) and we can feel it starting again.</p><p>We're not going to ignore everyone or forbid ourselves from using fedi, Discord, or other such places we frequent, but we need to cut back and recharge a bit.</p><p>We've got a number of stressors IRL right now, and we're only even functional due to a combination of an SSRI (setraline, 150 mg daily) and an NDRI (bupropion, 150 mg daily).</p><p>The bupropion is probably the only reason we're able to deal with any of our AuDHD stuff right now 😅 However, it's also let us push ourselves beyond our safe limits until we basically... break.</p><p>We're a neurodivergent spoonie. If we push ourselves too far, sometimes we will literally lose the ability to speak out loud. There have even been occasions where Hannah (Evie's lovely headmate) has had to dictate to Evie what to write in WhatsApp messages to her wife!!!</p><p>So, just to clarify, we're not stepping away, but we are stepping back a little bit from the support we've been offering people.</p><p>Anyways, that's enough for now. Sorry for the long post.</p><p>Please look after yourselves, okay? :PleadingFaceWithRedHearts: </p><p>We will return. Promise.</p><p><a href="https://cultofshiv.wtf/tags/burnout" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>burnout</span></a> <a href="https://cultofshiv.wtf/tags/neurodivergent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurodivergent</span></a> <a href="https://cultofshiv.wtf/tags/neurodivergence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurodivergence</span></a> <a href="https://cultofshiv.wtf/tags/AuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AuDHD</span></a> <a href="https://cultofshiv.wtf/tags/autistic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>autistic</span></a> <a href="https://cultofshiv.wtf/tags/ADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ADHD</span></a> <a href="https://cultofshiv.wtf/tags/spoonie" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>spoonie</span></a> <a href="https://cultofshiv.wtf/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MentalHealth</span></a> <a href="https://cultofshiv.wtf/tags/SSRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SSRI</span></a> <a href="https://cultofshiv.wtf/tags/NDRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NDRI</span></a> <a href="https://cultofshiv.wtf/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://cultofshiv.wtf/tags/bupropion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bupropion</span></a></p>
SleepyCatten<p>A major advantage of bupropion (NDRI) is that it's helping massively with my depression along sertraline (SSRI), and has also helped with the worst struggles we were experiencing with our ADHD, which we would have described as inattentive type before bupropion.</p><p>Our worst struggles previously were:</p><ul><li>Lack of executive function.</li><li>Not being able to easily start tasks or even start playing a new game!</li><li>Prioritising tasks appropriately.</li><li>Struggling to do any dull task.</li></ul><p>Now, everyday we feel like how some combined or hyperactive people on a stimulant like lisdexamfetamine describe themselves as feeling.</p><p>On bupropion, we are:</p><ul><li>Full of energy.</li><li>Able to focus on a task, or even juggle a few tasks at once.</li><li>No longer having to nap every night after work.</li><li>Actually enjoying our work tasks, even the duller ones.</li><li>Able to speak and think quicker.</li></ul><p>The only downsides are ones that we're happy to adapt to, such as:</p><ul><li>Being able to keep going until we literally crash, which can cause use to go mute 😅</li><li>Getting fixated and hyperfocussed on tasks much more easily.</li><li>Focussing so much on tasks that need doing that we forget to take breaks for gaming etc.</li><li>Being able to be a bit more spontaneous (which fights with our autistic side).</li><li>Talking even more than we did before 😅</li></ul><p><a href="https://cultofshiv.wtf/tags/bupropion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bupropion</span></a> <a href="https://cultofshiv.wtf/tags/ADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ADHD</span></a> <a href="https://cultofshiv.wtf/tags/autistic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>autistic</span></a> <a href="https://cultofshiv.wtf/tags/AuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AuDHD</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyADHD</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyAutistic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyAutistic</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyAuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyAuDHD</span></a> <a href="https://cultofshiv.wtf/tags/neurodivergent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurodivergent</span></a> <a href="https://cultofshiv.wtf/tags/neurodivergence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurodivergence</span></a> <a href="https://cultofshiv.wtf/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MentalHealth</span></a> <a href="https://cultofshiv.wtf/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> <a href="https://cultofshiv.wtf/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://cultofshiv.wtf/tags/SSRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SSRI</span></a> <a href="https://cultofshiv.wtf/tags/NDRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NDRI</span></a></p>
SleepyCatten<p>SleepyCatten's log.</p><p>Earth date: 2024-07-04.</p><p>We're down to 125 mg venlafaxine daily, along 50 mg setraline and 150 mg bupropion.</p><p>We've made a minor adjustment to our original scheduled regimen. On 6th July, when our venlafaxine dose decreases to 112.5 mg, we'll up our setraline dose to 75 mg then, rather than increasing it straight up to 100 mg on 12th July without an intermediate step. (It helps to have a precise pill cutter.)</p><p>What's kinda funny is that the longer we're on bupropion, the more we're acting a bit more like a stereotypical combined / hyperactive ADHD person on ADHD meds allowing them to focus. But unlike how other ADHD meds work (i.e., they may be short-lived, or last for maybe part of a day), the effect on bupropion is constant.</p><p>We're still having to be careful, as despite having the mental energy to do more stuff, we keep pushing ourselves too hard and overloading ourselves, particularly our speech centre. (Yep: we can go completely non-verbal if we overload.)</p><p>NGL though: bupropion is awesome and it's a disgrace that the NHS won't prescribe this in the UK. It could help SO many people with ADHD and depression!</p><p><a href="https://cultofshiv.wtf/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MentalHealth</span></a> <a href="https://cultofshiv.wtf/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> <a href="https://cultofshiv.wtf/tags/TreatmentResistantDepression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TreatmentResistantDepression</span></a> <a href="https://cultofshiv.wtf/tags/SNRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SNRI</span></a> <a href="https://cultofshiv.wtf/tags/SSRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SSRI</span></a> <a href="https://cultofshiv.wtf/tags/NDRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NDRI</span></a> <a href="https://cultofshiv.wtf/tags/venlafaxine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>venlafaxine</span></a> <a href="https://cultofshiv.wtf/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://cultofshiv.wtf/tags/bupropion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bupropion</span></a> <a href="https://cultofshiv.wtf/tags/SleepyCattenLog" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SleepyCattenLog</span></a> <a href="https://cultofshiv.wtf/tags/AuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AuDHD</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyAuDHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyAuDHD</span></a> <a href="https://cultofshiv.wtf/tags/ADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ADHD</span></a> <a href="https://cultofshiv.wtf/tags/ActuallyADHD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ActuallyADHD</span></a></p>
SleepyCatten<ul><li>SNRI - serotonin-noradrenaline reuptake inhibitor</li><li>SSRI - selective serotonin reuptake inhibitor</li><li>NDRI - noradrenaline-dopamine reuptake inhibitor</li></ul><p>Hey folks</p><p>As many of you will know, we've been struggling a <strong>lot</strong> rather too frequently recently.</p><p>After a <strong>lot</strong> of research and reading up, we asked our GP to switch us over from venlafaxine (SNRI) to setraline (SSRI).</p><p>In order to do this, we first need to slowly titrate down from 375 to 150 mg daily of venlafaxine. It needs to be done slowly, as coming off venlafaxine too quickly (or even missing a dose) can cause super nasty withdrawal symptoms.</p><p>Fortunately for us, the venlafaxine capsules we get (Vencarm XL) each contain an appropriate number of 12.5 mg tablets. This makes it very easy to titrate down slowly, by removing a set number of tablets from each capsule.</p><p>We'll be gradually reducing our dose by 12.5 mg every other day. This should hopefully allow our brain to gradually adapt to the lessened serotonin and noradrenaline levels, rather than going down in single big steps of 37.5 or 75 mg weekly.</p><p>Our GP will then prescribe us 50 mg sertraline daily to take alongside as we continue to titrate down our daily venlafaxine dose. </p><p>Assuming no negative side effects (or at least no more than on venlafaxine), our GP can then increase the setraline dose as required, likely to 100 mg.</p><p>If there are negative side effects with sertraline, we have backup plans of fluoxetine and, if necessary, citalopram (which we've had before).</p><p>Once we're off venlafaxine and on a stable dose of an SSRI, we will then start taking bupropion (NDRI) extended release at the starting dose of 150 mg daily. This should help boost our noradrenaline and dopamine levels somewhat, which should, alongside the setraline, should help more than venlafaxine ever did.</p><p>We sadly can't get bupropion through the NHS, so we'll have to acquire it via means outside of the NHS prescription system. Yes: NHS England and NICE are quite a bit behind the times on many things.</p><p>In case anyone is wondering why we would even consider an initial switch from an SNRI to an SSRI in the first place, it's because we discovered that it really doesn't boost noradrenaline levels by much: as little as 1/30th to 1/10th as much as it boosts serotonin, depending on dose.</p><p>Additionally, venlafaxine just isn't working for us, and our only realistic remaining option medically is to switch to an SSRI first, then bring in a well-reviewed NDRI to give us a decent boost in noradrenaline and dopamine.</p><p><a href="https://cultofshiv.wtf/tags/SNRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SNRI</span></a> <a href="https://cultofshiv.wtf/tags/SSRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SSRI</span></a> <a href="https://cultofshiv.wtf/tags/NDRI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NDRI</span></a> <a href="https://cultofshiv.wtf/tags/venlafaxine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>venlafaxine</span></a> <a href="https://cultofshiv.wtf/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://cultofshiv.wtf/tags/fluoxetine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fluoxetine</span></a> <a href="https://cultofshiv.wtf/tags/citalopram" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>citalopram</span></a> <a href="https://cultofshiv.wtf/tags/bupropion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bupropion</span></a> <a href="https://cultofshiv.wtf/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> <a href="https://cultofshiv.wtf/tags/TreatmentResistantDepression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TreatmentResistantDepression</span></a> <a href="https://cultofshiv.wtf/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MentalHealth</span></a></p>
MikeFromLFE<p>The new antidepressant I've been given - <a href="https://mastodon.me.uk/tags/mirtazapine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mirtazapine</span></a> - has been 'interesting'.</p><p>I took the first 15mg tablet at 8pm on Wednesday. I then spent 17 of the next 24 hours asleep!</p><p>The second dose, last night, doesn't seem, yet, to be having quite such a dramatic effect. </p><p>I had some crazy dreams last night, and this morning I feel like I've got flu. That's probably due to the withdrawal from <a href="https://mastodon.me.uk/tags/Sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sertraline</span></a>. </p><p>Thankfully the <a href="https://mastodon.me.uk/tags/grandchildren" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>grandchildren</span></a> are being really good for Mrs Mike</p>
MikeFromLFE<p><a href="https://mastodon.me.uk/tags/today" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>today</span></a> is happening at reduced speed.</p><p>The withdrawal from the <a href="https://mastodon.me.uk/tags/Sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sertraline</span></a> isn't going well.<br>I feel dreadful both physically and mentally.</p><p>Mrs Mike is struggling with her arthritis and daughter's issues. </p><p>Speaking of which - Daughter is barely communicating. But our son is on the case to take some of the load.</p><p>Still, I've had breakfast without throwing up, and done some of the <a href="https://mastodon.me.uk/tags/housework" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>housework</span></a>.<br>Time for a cuppa.</p><p>Sorry for moaning</p><p><a href="https://mastodon.me.uk/tags/mentalhealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mentalhealth</span></a></p>
MikeFromLFE<p>I originally started <a href="https://mastodon.me.uk/tags/Sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sertraline</span></a> for <a href="https://mastodon.me.uk/tags/anxiety" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>anxiety</span></a> but then daughter's <a href="https://mastodon.me.uk/tags/EUPD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EUPD</span></a> got much worse and the GP advised increasing the dose to deal with my new symptoms of <a href="https://mastodon.me.uk/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a>.</p><p>I now want to come off the stuff as it makes me feel unwell and the depression is pretty much under control, but I think it's worked for anxiety.</p><p>Having a sensible (that's face to face) discussion with a GP is almost impossible at our surgery - they love their telephone consultations.</p><p>Sigh.</p><p><a href="https://mastodon.me.uk/tags/mentalhealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mentalhealth</span></a> <a href="https://mastodon.me.uk/tags/BPD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BPD</span></a></p>
MikeFromLFE<p>I slept much better than I expected - normally when <a href="https://mastodon.me.uk/tags/ibs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ibs</span></a> is flaring up I sleep really badly. Hopefully this was a short sharp shock!</p><p>One of the other positive side effects of <a href="https://mastodon.me.uk/tags/Sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sertraline</span></a> has been to calm down my guts. I no longer seem to be as sensitive to various foods and my stress levels are generally under control. </p><p>(I'm convinced my IBS isn't predominantly a diet thing, and, I've not really been in a stressful situation that would be a trigger)</p>
MikeFromLFE<p>I've just realised - I feel OK, actually I feel good.<br>It's the first time in possibly months that I can say I don't feel like I'm carrying a heavy mental load. <br><a href="https://mastodon.me.uk/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> is sh¡t</p><p>I don't know if it's the <a href="https://mastodon.me.uk/tags/sunshine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sunshine</span></a> or the <a href="https://mastodon.me.uk/tags/Sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sertraline</span></a> or a cathartic effect of yesterday's mini-migraine but I'll take it, and more besides.</p><p>Roll on Wednesday</p>
King<p>Bro have you ever notice that <a href="https://mindly.social/tags/Zoloft" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Zoloft</span></a> smells like straight up vanilla cake?</p><p><a href="https://mindly.social/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> <a href="https://mindly.social/tags/antidepressants" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>antidepressants</span></a> <a href="https://mindly.social/tags/ssri" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ssri</span></a> <a href="https://mindly.social/tags/SSRIs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SSRIs</span></a> <a href="https://mindly.social/tags/moodstabilizers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>moodstabilizers</span></a> <a href="https://mindly.social/tags/depression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>depression</span></a> <a href="https://mindly.social/tags/mooddisorders" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mooddisorders</span></a></p>
Michael<p><span class="h-card"><a href="https://mastodon.world/@joeharkness" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>joeharkness</span></a></span> I don't take <a href="https://ms1.me/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a>, but I take <a href="https://ms1.me/tags/quetiapine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>quetiapine</span></a> for <a href="https://ms1.me/tags/cyclothymia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cyclothymia</span></a> and I often wonder the same. I do miss some of the productivity from the highs, but being balanced more of the time is much more valuable. Maybe one day I'll try reducing and coming off them, but it's about finding the time for a period of adjustment and being in the right frame of mind</p>
Muninn 🍃<p>I had similar effects from <a href="https://social.coop/tags/sertraline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sertraline</span></a> (<a href="https://social.coop/tags/zoloft" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Zoloft</span></a>) long ago, but not from <a href="https://social.coop/tags/prozac" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Prozac</span></a>. These meds twiddle serotonin, so it's not too surprising that some people might feel subtle psychedelic effects upon dosage change.</p><p>It's also interesting that the serotonergic <a href="https://social.coop/tags/psychedelics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>psychedelics</span></a> (<a href="https://social.coop/tags/lsd" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LSD</span></a>, <a href="https://social.coop/tags/psilocybin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>psilocybin</span></a>, <a href="https://social.coop/tags/mescaline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mescaline</span></a>, even <a href="https://social.coop/tags/mdma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MDMA</span></a>) have antidepressant effects.</p><p>So too do the atypical antipsychotics - some twiddle the exact same receptor as the psychedelics, but turn the knob the opposite way.</p>
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